Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice

@article{Yesilyurt2016SystemicAS,
  title={Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice},
  author={Ozgur Yesilyurt and Mutlu Çayirli and Yusuf Serdar Sakin and Melik Seyrek and Ahmet R{\"u}çhan Akar and Ahmet Bulent Dogrul},
  journal={Archives of Dermatological Research},
  year={2016},
  volume={308},
  pages={335-345}
}
The increase of endocannabinoid tonus by inhibiting fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL) represents a promising therapeutic approach in a variety of disease to overcome serious central side effects of exocannabinoids. Recent studies reported that systemic administration of FAAH and MAGL inhibitors produce antipruritic action. Dual FAAH/MAGL inhibitors have also been described to get enhanced endocannabinoid therapeutic effect. In this study, we examined and… CONTINUE READING
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