Systemic and renal hemodynamic effects of bupicomide: a new vasodilator.

  title={Systemic and renal hemodynamic effects of bupicomide: a new vasodilator.},
  author={S. Chrysant and P. Adamopoulos and M. Tsuchiya and E. Frohlich},
  journal={American heart journal},
  volume={92 3},
The systemic and renal hemodyanmic effects of bupicomide were studied in 10 male patients with uncomplicated essential hypertension of moderate severity. Bupicomide significantly reduced systolic, diastolic, and mean arterial pressure and peripheral vascular resistance and this hypotensive effect was associated with a reflexive increase in heart rate, left ventricular ejection rate, and cardiac index; it had no effect upon other reflexive sympathetic adjustments induced by upright tilt and the… Expand
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Ticrynafen is a promising therapeutic agent in hypertension, adding a unique uricosuric effect that should improve patient compliance. Expand
Chapter 7: Antihypertensive Agents
Publisher Summary Hypertension results from a repeated sequence of small rises in blood pressure, because of sympathetic hyperactivity, that produce changes in the kidney. The roles of cadmium, lead,Expand
Methods for the assessment of the effects of drugs on renal blood flow.
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  • Chemistry, Medicine
  • British journal of clinical pharmacology
  • 1979
In man, total renal blood flow is about 1.2 1/min, some 25% of the cardiac output and therefore of considerable circulatory importance and there has been increasing interest in accurate methods for its measurement. Expand
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Synthesis, structures, and investigation of noncovalent interactions of 1,3-dimethyl-5-(4ʹ/3ʹ-pyridylazo)-6-aminouracil and their Ni(II) complexes
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Pathophysiological mechanisms in essential hypertension.


Treatment of essential hypertension with a new vasodilator in combination with beta-adrenergic blockade.
A new piperidino-pyrimidine vasodilator when used in the treatment of 11 hypertensive patients, lowered blood pressure from 188/124 to 159/100 over six to seven days, and retention of sodium retention occurred in all patients. Expand
Combined Therapy with Vasodilator Drugs and Beta‐Adrenergic Blockade in Hypertension: A Comparative Study of Minoxidil and Hydralazine
The role of vasodilators used in combination with beta-blockers and diuretics is suggested and the greater therapeutic efficacy of minoxidil is indicated. Expand
Cardiovascular and renal adjustments to a hypotensive agent (l'hydrazinophthalazine: Ciba BA-5968: apresoline).
Since the work of Goldblatt, Lynch, Hanzal, and Summerville which related renal ischemia causally to hypertension (1), it has seemed logical to use renal vasodilators in the treatment of theExpand
Direct renal hemodynamic effects of two vasodilators: diazoxide and acetylcholine.
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II. HEMODYNAMIC ASPECTS OF HYPERTENSION: Physiological Comparison of Labile and Essential Hypertension
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Renal Hyperemia Induced in Man by a New Phthalazine Derivative
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  • Medicine
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  • 1950
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Plasma Volume Expansion Resulting from Interference with Adrenergic Function in Normal Man
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Blood volume and exchangeable sodium during treatment of hypertension with guanethidine and hydrochlorothiazide.
Antipressor treatment with guanethidine for 8 to 14 days and supplementary treatment with hydrochlorothiazide resulted in a normalization of the above-mentioned parameters both during short-term and long-term management. Expand
The Effect of 1‐Hydrazinophthalazine in Hypertension
The compound 1-hydrazinophthalazine appears to be be an antihypertensive drug of only moderate potency. Based on experience with 50 cases of arterial hypertension, it was found most effective inExpand