Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer.

@article{Heusinkveld2012SystemicAL,
  title={Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer.},
  author={Moniek Heusinkveld and Renske Goedemans and R J P Briet and Hans Gelderblom and Johan W. R. Nortier and Arko Gorter and Vincent T. H. B. M. Smit and Antonius P M Langeveld and Jeroen C. Jansen and Sjoerd H. van der Burg},
  journal={International journal of cancer},
  year={2012},
  volume={131 2},
  pages={E74-85}
}
Squamous cell carcinomas of the head and neck (HNSCC), in particular those of the oropharynx, can be caused by human papilloma virus Type 16 (HPV16). Whereas these HPV-induced oropharyngeal carcinomas may express the HPV16 E6 and E7 oncoproteins and are associated with better survival, the nonvirally induced HNSCC are associated with overexpression of p53… CONTINUE READING