Systemic and compartmentalised immune responses in a Leishmania braziliensis-macaque model of self-healing cutaneous leishmaniasis.

@article{deCampos2010SystemicAC,
  title={Systemic and compartmentalised immune responses in a Leishmania braziliensis-macaque model of self-healing cutaneous leishmaniasis.},
  author={Simone Neves de-Campos and Camila Souza-Lemos and Ant{\^o}nio T{\^e}va and Renato Porrozzi and Gabriel Grimaldi},
  journal={Veterinary immunology and immunopathology},
  year={2010},
  volume={137 1-2},
  pages={149-54}
}
We have recently introduced a macaque (Macaca mulatta) model of Leishmania braziliensis-induced chronic granulomatous cutaneous lesions affecting the nasal mucosa. Using an L. braziliensis strain that produces self-healing dermal lesions in macaques, here we characterises the systemic and local cell-mediated immune responses that led to controlled growth of granulomas in the infected host. As detected using flow cytometry, more cytokine-producing T-cell subsets were observed in granuloma… CONTINUE READING
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