Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.

@article{Diao2014SystemicAC,
  title={Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.},
  author={Chengfeng Diao and Liangcai Zhao and Mimi Guan and Yongquan Zheng and Minjiang Chen and Yunjun Yang and Li Lin and Weijian Chen and Hongchang Gao},
  journal={Molecular bioSystems},
  year={2014},
  volume={10 3},
  pages={686-93}
}
Diabetes mellitus is a typical heterogeneous metabolic disorder characterized by abnormal metabolism of carbohydrates, lipids, and proteins. Investigating the changes in metabolic pathways during the evolution of diabetes mellitus may contribute to the understanding of its metabolic features and pathogenesis. In this study, serum samples were collected from diabetic rats and age-matched controls at different time points: 1 and 9 weeks after streptozotocin (STZ) treatment. (1)H nuclear magnetic… CONTINUE READING