Systemic and cell type-specific gene expression patterns in scleroderma skin.

@article{Whitfield2003SystemicAC,
  title={Systemic and cell type-specific gene expression patterns in scleroderma skin.},
  author={Michael L. Whitfield and Deborah R Finlay and John Isaac Murray and Olga G. Troyanskaya and Jen-Tsan Chi and Alexander Pergamenschikov and Timothy H McCalmont and Patrick O. Brown and David Botstein and M. Kari Connolly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 21},
  pages={12319-24}
}
We used DNA microarrays representing >12,000 human genes to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma. We found consistent differences in the patterns of gene expression between skin biopsies from individuals with scleroderma and those from normal, unaffected individuals. The biopsies from affected individuals showed nearly indistinguishable patterns of gene expression in clinically affected and… CONTINUE READING
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