Systemic and cell type-specific gene expression patterns in scleroderma skin.

  title={Systemic and cell type-specific gene expression patterns in scleroderma skin.},
  author={Michael L. Whitfield and Deborah R Finlay and John Isaac Murray and Olga G. Troyanskaya and Jen-Tsan Chi and Alexander Pergamenschikov and Timothy H McCalmont and Patrick O. Brown and David Botstein and M. Kari Connolly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 21},
We used DNA microarrays representing >12,000 human genes to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma. We found consistent differences in the patterns of gene expression between skin biopsies from individuals with scleroderma and those from normal, unaffected individuals. The biopsies from affected individuals showed nearly indistinguishable patterns of gene expression in clinically affected and… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.
131 Citations
28 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 131 extracted citations


Publications referenced by this paper.
Showing 1-10 of 28 references

Int. J. Dermatol

  • J Pomann, E Rudner
  • Int. J. Dermatol
  • 2003

N. Engl. J. Med

  • M Sarwal, M S Chua, +4 authors O Salvatierra
  • N. Engl. J. Med
  • 2003


  • O G Troyanskaya, M E Garber, P O Brown, D Botstein, R B Altman
  • Bioinformatics
  • 2002

J. Clin. Invest

  • E Saito, M Fujimoto, +7 authors S Sato
  • J. Clin. Invest
  • 2002


  • L Scussel-Lonzetti, F Joyal, +5 authors J L Senecal
  • Medicine
  • 2002

Proc. Natl. Acad. Sci. USA 99

  • H Y Chang, J T Chi, S Dudoit, C Bondre
  • Proc. Natl. Acad. Sci. USA 99
  • 2002

Am. J. Dermatopathol

  • S Cowper, L Su, J Bhawan, H Robin, P Leboit
  • Am. J. Dermatopathol
  • 2001


  • H A Fisk, M Winey
  • Cell
  • 2001

J. Immunol

  • X Zhou, F K Tan, +5 authors F C Arnett
  • J. Immunol
  • 2001

Kelley's Textbook of Rheumatology

  • J R Seibold
  • Kelley's Textbook of Rheumatology
  • 2001

Similar Papers

Loading similar papers…