Systemic and Tumor Th1 and Th2 Inflammatory Profile and Macrophages in Lung Cancer: Influence of Underlying Chronic Respiratory Disease

@article{MateuJimnez2017SystemicAT,
  title={Systemic and Tumor Th1 and Th2 Inflammatory Profile and Macrophages in Lung Cancer: Influence of Underlying Chronic Respiratory Disease},
  author={M. Mateu-Jim{\'e}nez and V. Curull and L. Pijuan and A. S{\'a}nchez-Font and Hugo Rivera-Ramos and A. Rodr{\'i}guez-Fuster and R. Aguil{\'o} and J. Gea and E. Barreiro},
  journal={Journal of Thoracic Oncology},
  year={2017},
  volume={12},
  pages={235–248}
}
Introduction: Chronic respiratory conditions, especially chronic obstructive pulmonary disease (COPD), and inflammatory events underlie lung cancer (LC). We hypothesized that profiles of T helper 1 and T helper 2 cytokines and type 1 and type 2 macrophages (M1 and M2) are differentially expressed in lung tumors and blood of patients with NSCLC with and without COPD and that the ratio M1/M2 specifically may influence their survival. Methods: In blood, inflammatory cytokines (determined by enzyme… Expand
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