Systemic and Tissue Inflammation in Juvenile Dermatomyositis: From Pathogenesis to the Quest for Monitoring Tools

@inproceedings{Wienke2018SystemicAT,
  title={Systemic and Tissue Inflammation in Juvenile Dermatomyositis: From Pathogenesis to the Quest for Monitoring Tools},
  author={Judith Wienke and Claire Tara Deakin and Lucy R Wedderburn and Femke van Wijk and Annet van Royen-Kerkhof},
  booktitle={Front. Immunol.},
  year={2018}
}
Juvenile Dermatomyositis (JDM) is a systemic immune-mediated disease of childhood, characterized by muscle weakness, and a typical skin rash. Other organ systems and tissues such as the lungs, heart, and intestines can be involved, but may be under-evaluated. The inflammatory process in JDM is characterized by an interferon signature and infiltration of immune cells such as T cells and plasmacytoid dendritic cells into the affected tissues. Vasculopathy due to loss and dysfunction of… CONTINUE READING

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