Systemic amyloidosis

@article{Wechalekar2016SystemicA,
  title={Systemic amyloidosis},
  author={Ashutosh D. Wechalekar and Julian D. Gillmore and Philip N. Hawkins},
  journal={The Lancet},
  year={2016},
  volume={387},
  pages={2641-2654}
}
Cardiac Amyloidosis: A Review of Current Imaging Techniques
TLDR
Key radiological features of CA are discussed, focusing on the two most common types; immunoglobulin light chain (AL) and transthyretin (ATTR) CA, highlighting recent advances in imaging techniques particularly in respect of their clinical application and utility in diagnosis of CA as well as for tracking disease change over time.
Amyloid cardiomyopathy.
  • Lucie Karafiatova, T. Pika
  • Medicine, Biology
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
  • 2017
TLDR
An overview of amyloidsosis is provided, providing information about the characteristics of cardiac amyloidosis, and a structured approach to diagnosis, treatment and prognosis of this condition is presented.
Advances in diagnostics and therapy of systemic amyloidoses
TLDR
Significant progress has been recently achieved concerning the first type of strategies in two most common systemic amyloidoses: AL and ATTR.
Diagnosis of amyloid beyond Congo red.
  • M. Picken
  • Medicine, Biology
    Current opinion in nephrology and hypertension
  • 2020
TLDR
Despite significant advances in the treatment of the systemic amyloidoses, outcomes remain poor, primarily due to delays in diagnosis, and Precise diagnosis of the amyloids protein type is critical for treatment selection.
Cardiac amyloidosis
TLDR
Recent developments in diagnosis and management of cardiac amyloidosis are reviewed, with a focus on transthyretin type cases.
Amyloidosis with Cardiac Involvement: Identification, Characterization, and Management
TLDR
Although cardiac amyloidosis contributes significantly to the morbidity and mortality associated with systemic disease, new tools are available to assist with diagnosis, prognosis, and management.
Recent advances in the diagnosis and management of amyloid cardiomyopathy
TLDR
Treatment of CA includes the management of restrictive cardiomyopathy with preserved or reduced ejection fraction in addition to treating the amyloid deposition, and it is likely that a multistep treatment approach will be optimal for both AL CA and ATTR CA.
A Case of Lambda AL Type Skeletal Amyloidosis with Vascular Myopathy Achieved Clinical Response after Autologous Stem Cell Transplant
TLDR
Early diagnosis of amyloidosis is a key to better outcomes, this results in disease progression-not to mention a more difficult time treating it-before it is finally discovered in a patient.
Mass spectrometry analysis for amyloidosis typing - is the future bright for its clinical implementation?
TLDR
With a new era of amyloid therapeutics upon us, such as antisense therapies, transthyretin stabilizers, and anti-amyloid fibril antibodies, accurate diagnosis has become more important than ever.
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It is suggested that ATTR fibrils may develop both from full-length TTR and from C-terminal TTR fragments and that the N- terminal part is not necessary for the fibril integrity.
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TLDR
Outcomes following RTx were generally excellent in these diseases, reflecting their slow natural history; median graft survival was 13.1 years and post‐RTx chemotherapy was administered successfully to four AL patients.
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