Systemic allergic dermatitis following airborne exposure to 1,2‐benzisothiazolin‐3‐one

@article{KaurKnudsen2012SystemicAD,
  title={Systemic allergic dermatitis following airborne exposure to 1,2‐benzisothiazolin‐3‐one},
  author={Diljit Kaur-Knudsen and Torkil Menn{\'e} and Berit Christina Carlsen},
  journal={Contact Dermatitis},
  year={2012},
  volume={67}
}
1,2-Benzisothiazolin-3-one (BIT) is a preservative used to prevent the growth of microorganisms in a number of industrial and household products, such as glues, cleaning agents, polishes, paint, and hardeners (1). BIT has been recognized as an allergen since 1976 (2), and has the ability to cause contact dermatitis with a sensitization rate of 1.3% (3). Severe skin reactions after direct cutaneous exposure to BIT have been reported in many different occupations (4–7). However, systemic contact… 
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Recent literature reports are focusing on occupational contact allergens such as biocides, resins, rubber additives, drugs, and, to a minor extent, botanically derived materials and metals.
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A 32-year-old man was referred to us because of severe widespread dermatitis caused by heavy exposure to the isothiazolinones MCI/MI and MI while working at a glue factory, and developed a 5-cm eczematous reaction on the left inner thigh extending up to the buttock.
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Methylisothiazolinone (MI) is a preservative that is responsible for an epidemic of allergic contact dermatitis (ACD). Few studies have been published on the prognosis of patients with MI‐induced ACD.
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TLDR
Occupational contact allergy to 1,2‐benzisothiazolin‐3‐one (1‐2‐BIT, proxel®) is analysed and true cross‐sensitivity was found to be unlikely.
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The carpet industry is identified as an additional source of occupational allergic contact dermatitis to BIT in the present case report.
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Two male employees in an industry producing plastic emulsions acquired contact dermatitis from preservative, i.e. 1,2-benzisothiazolin-3-one and ethylene diamine.
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The frequent registration of isothiazolinones (MCI/MI and benzisothiazolone) in paints/lacquers may be a possible explanation for the relative high and stable frequency of positive patch test reactions to MCI/ MI.
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