Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys.

Abstract

Systemic administration of immunophilin ligands provides trophic influences to dopaminergic neurons in rodent models of Parkinson's disease (PD) resulting in the initiation of clinical trials in patients with Parkinson's disease. We believe that prior to clinical trials, novel therapeutic strategies should show safety and efficacy in nonhuman models of PD… (More)

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@article{Emborg2001SystemicAO, title={Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys.}, author={Marina E. Emborg and Peter Shin and B. D. Roitberg and Jiř{\'i} {\vS}r{\'a}mek and Y. Chu and Glenn T. Stebbins and J. S. Hamilton and Peter D. Suzdak and Joseph P. Steiner and Jeffrey H. Kordower}, journal={Experimental neurology}, year={2001}, volume={168 1}, pages={171-82} }