Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

@article{Ruschel2015SystemicAO,
  title={Systemic administration of epothilone B promotes axon regeneration after spinal cord injury},
  author={J{\"o}rg Ruschel and Farida Hellal and Kevin Christopher Flynn and Sebastian Enrique Dupraz and David A Elliott and Andrea Tedeschi and Margaret Longest Bates and Christopher Sliwinski and Gary Brook and Kristina Dobrindt and Michael Peitz and Oliver Bruestle and M D Norenberg and Armin Blesch and Norbert Weidner and Mary Bartlett Bunge and John L. Bixby and Frank Bradke},
  journal={Science},
  year={2015},
  volume={348},
  pages={347-352}
}
After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and promotes axon growth. However, the cellular mechanisms of this dual effect remain unclear. Here, delayed systemic administration of a blood-brain barrier–permeable microtubule-stabilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abrogating polarization and directed… CONTINUE READING
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