Systemic administration of doxorubicin impairs aversively motivated memory in rats.

@article{Liedke2009SystemicAO,
  title={Systemic administration of doxorubicin impairs aversively motivated memory in rats.},
  author={Pedro Emanuel Rubini Liedke and Gustavo Kellermann Reolon and Bruno Kilpp and Algemir Lunardi Brunetto and Rafael Roesler and Gilberto Schwartsmann},
  journal={Pharmacology, biochemistry, and behavior},
  year={2009},
  volume={94 2},
  pages={239-43}
}
There is growing clinical evidence of cognitive impairment in cancer patients treated with chemotherapy, especially in women treated with drug combinations for breast cancer. Clinical studies have a difficult task of defining which drugs individually are responsible for the cognitive changes and published papers evaluating single agents in experimental models are scanty. In the present study we have investigated the effect of single escalating doses of doxorubicin (DOX) on memory for inhibitory… CONTINUE READING

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