Systemic administration of a peptide that impairs the protein kinase (CK2) phosphorylation reduces solid tumor growth in mice

@article{Perera2008SystemicAO,
  title={Systemic administration of a peptide that impairs the protein kinase (CK2) phosphorylation reduces solid tumor growth in mice},
  author={Yasser Perera and Hern{\'a}n G. Farina and Ignacio Hern{\'a}ndez and Osmany Mendoza and Joem M. Serrano and Osvaldo Reyes and Daniel Eduardo Gomez and Roberto E. G{\'o}mez and Boris E. Acevedo and Daniel Fernando Alonso and Silvio E. Perea},
  journal={International Journal of Cancer},
  year={2008},
  volume={122}
}
The antitumor efficacy of the CK2 inhibitors so far described has not been extensively evaluated in cancer animal models. We have previously demonstrated that a proapoptotic cyclic peptide termed P15 delivered into the cells by the Tat Cell Penetrating Peptide was able to abrogate the CK2‐mediated phosphorylation and induce tumor regression when injected directly into solid tumors in mice. Here we explored the antitumor effect by systemic administration of P15‐Tat in a consecutive 5‐day… 
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66 Citations
Background Citations
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Methods Citations
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66 Citations

CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo

These results provide an early proof-of-principle of clinical benefit by using an anti-CK2 approach in cancer and are the first clinical trial where an investigational drug has been used to target the CK2 phosphorylation domain.

CIGB-300, a proapoptotic peptide, inhibits angiogenesis in vitro and in vivo.

Targeting of Protein Kinase CK2 in Acute Myeloid Leukemia Cells Using the Clinical-Grade Synthetic-Peptide CIGB-300

The results not only provide cellular and molecular insights unveiling the complexity of the CIGB-300 anti-leukemic effect in AML cells, but also reinforce the rationale behind the pharmacologic blockade of protein kinase CK2 for AML targeted therapy.

CIGB-300, an anti-CK2 peptide, inhibits angiogenesis, tumor cell invasion and metastasis in lung cancer models.

Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice

It is proposed that the molecular downregulation of CK2 through bispecific targeting of the two catalytic subunits may be uniquely useful for therapeutic elimination of tumors.

Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization

Encouraging results suggest that CIGB-300 could be used for the management of breast cancer as an adjuvant therapy after surgery, limiting tumor metastatic spread and thus protecting the patient from distant recurrence.

Sensitivity of tumor cells towards CIGB‐300 anticancer peptide relies on its nucleolar localization

This work evidenced that CIGB‐300's antiproliferative activity on tumor cells strongly correlates with its nucleolar localization, the main subcellular localization of the previously identified B23/NPM target, and suggests that further improvements to this cell penetrating peptide‐based drug should entail its more efficient intracellular delivery at such sub cellular localization.

Targeting CK2 for Cancer Therapy Using a Nanomedicine Approach

Protected and malignant cell-specific delivery of a therapeutic is a promising target-specific and versatile approach for cancer therapy, and both the TBG encapsulation technology and the anti-CK2 oligonucleotide approach demonstrate substantial potential for the treatment of malignancy.

A casein kinase 2 inhibitor is a potent anti-cancer drug candidate

In vitro DMAT induces significant proliferation arrest and apoptosis at a similar level in all the cancer cell lines tested, and an in vivo pilot toxicity study showed that DMAT is not toxic to mice.

CIGB-300: A peptide-based drug that impairs the Protein Kinase CK2-mediated phosphorylation.

The clinical data demonstrate the safety, tolerability, and clinical effects of intratumoral injections of CIGB-300 and provide the foundation for future phase 3 clinical trials in locally advanced cervical cancer in combination with standard chemoradiotherapy.
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References

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A new proapoptotic cyclic peptide is identified that blocks the CK2 phosphorylation and exhibits antitumor effect in vivo, indicating that the P15 peptide may potentially be used clinically to treat solid tumors or as an adjuvant for cancer therapy.

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