Systemic administration of a novel octapeptide, amylin-(1---8), increases bone volume in male mice.

@article{Cornish2000SystemicAO,
  title={Systemic administration of a novel octapeptide, amylin-(1---8), increases bone volume in male mice.},
  author={Jillian Cornish and Karen E. Callon and James A. Gasser and Usha Bava and Edith M. Gardiner and DavidH. Coy and G. J. Cooper and Ian R Reid},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={279 4},
  pages={
          E730-5
        }
}
Amylin increases bone mass when administered systemically to mice. However, because of its size, the full peptide is not an ideal candidate for the therapy of osteoporosis. The fragment, amylin-(1---8), stimulates osteoblast proliferation in vitro, although it is without effect on carbohydrate metabolism. The present study assessed the effects of daily administration of this peptide on sexually mature male mice for 4 wk. Amylin-(1---8) almost doubled histomorphometric indices of osteoblast… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 14 REFERENCES

Dissociation of the effects of amylin on osteoblast proliferation and bone resorption.

  • The American journal of physiology
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Comparison of the effects of calcitonin gene-related peptide and amylin on osteoblasts.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1999
VIEW 1 EXCERPT

Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1999
VIEW 1 EXCERPT

Calcitonin gene-related peptide, amylin, or parathyroid hormone stimulate (in vitro) biomineralization (Abstract)

MD Burns, T. Kawase
  • J Bone Miner Res 12 Suppl
  • 1997
VIEW 2 EXCERPTS

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