Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice.

@article{Gordon2001SystemicAO,
  title={Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice.},
  author={Erlinda M. Gordon and Zhen Hai Chen and Lin Wei Liu and Michelle D. Whitley and Denise Wei and Susan Groshen and David R Hinton and W. French Anderson and Robert W. Beart and Frederick L. Hall},
  journal={Human gene therapy},
  year={2001},
  volume={12 2},
  pages={193-204}
}
Targeting cytocidal vectors to tumors and associated vasculature in vivo is a long-standing goal of human gene therapy. In the present study, we demonstrated that intravenous infusion of a matrix (i.e., collagen)-targeted retroviral vector provided efficacious gene delivery of a cytocidal mutant cyclin G1 construct (designated Mx-dnG1) in human cancer… CONTINUE READING