Systemic administration of a deoxyribozyme to xylosyltransferase-1 mRNA promotes recovery after a spinal cord contusion injury

@article{Oudega2012SystemicAO,
  title={Systemic administration of a deoxyribozyme to xylosyltransferase-1 mRNA promotes recovery after a spinal cord contusion injury},
  author={Martin Oudega and Owen Yuan-Hsin Chao and Donna L. Avison and Roderick T Bronson and William J. Buchser and Andr{\'e}s Hurtado and Barbara Grimpe},
  journal={Experimental Neurology},
  year={2012},
  volume={237},
  pages={170-179}
}
After spinal cord injury, proteoglycans with growth-inhibitory glycosaminoglycan (GAG-) side chains in scar tissue limit spontaneous axonal sprouting/regeneration. Interventions that reduce scar-related inhibition facilitate an axonal growth response and possibly plasticity-based spinal cord repair. Xylosyltransferase-1 (XT-1) is the enzyme that initiates GAG-chain formation. We investigated whether intravenous administration of a deoxyribozyme (DNA enzyme) to XT-1 mRNA (DNAXT-1as) would elicit… 
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TLDR
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