Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice.

Abstract

The absence of dystrophin and resultant disruption of the dystrophin glycoprotein complex renders skeletal muscles of dystrophic patients and dystrophic mdx mice susceptible to contraction-induced injury. Strategies to reduce contraction-induced injury are of critical importance, because this mode of damage contributes to the etiology of myofiber breakdown… (More)

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@article{Schertzer2006SystemicAO, title={Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice.}, author={Jonathan D. Schertzer and James G. Ryall and Gordon S Lynch}, journal={American journal of physiology. Endocrinology and metabolism}, year={2006}, volume={291 3}, pages={E499-505} }