Systemic administration of 6-OHDA to rhesus monkeys upregulates HLA-DR expression in brain microvasculature

@inproceedings{Joers2014SystemicAO,
  title={Systemic administration of 6-OHDA to rhesus monkeys upregulates HLA-DR expression in brain microvasculature},
  author={Valerie L Joers and Scott Christopher Vermilyea and Kristine Dilley and Marina E. Emborg},
  booktitle={Journal of inflammation research},
  year={2014}
}
BACKGROUND We recently developed a nonhuman primate model of cardiac dysautonomia by systemic dosing of the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA). The aim of this study was to assess whether systemic 6-OHDA affects the central nervous system of nonhuman primates, in particular the dopaminergic nigrostriatal system. METHODS Brain sections from adult rhesus monkeys that received systemic 6-OHDA (50 mg/kg intravenously; n=5) and were necropsied 3 months later, as well as normal… CONTINUE READING

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