Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus.

@article{Chu2009SystemicAO,
  title={Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus.},
  author={Van Trung Chu and Philipp Enghard and Stefanie Schuerer and Gudrun Steinhauser and Birgit Rudolph and Gabriela Riemekasten and Claudia Berek},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 7},
  pages={2083-93}
}
OBJECTIVE Elevated levels of BAFF and APRIL are characteristic of patients with systemic lupus erythematosus (SLE). The reasons for enhanced cytokine production are not well understood. This study was undertaken to identify the cells responsible for the overproduction of these cytokines. METHODS BAFF expression was analyzed on peripheral blood mononuclear cells by multiparameter flow cytometry and in tissue samples by immunofluorescence staining. The levels of BAFF and APRIL mRNA were… CONTINUE READING
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