Systemic activation of basophils and eosinophils: markers and consequences.

@article{Bochner2000SystemicAO,
  title={Systemic activation of basophils and eosinophils: markers and consequences.},
  author={Bruce S Bochner},
  journal={The Journal of allergy and clinical immunology},
  year={2000},
  volume={106 5 Suppl},
  pages={S292-302}
}
  • Bruce S Bochner
  • Published 2000 in The Journal of allergy and clinical immunology
Basophils and eosinophils are important effector cells in human allergic diseases; they play a significant role in promoting allergic inflammation through the release of proinflammatory mediators (such as histamine, leukotriene C(4), major basic protein, eosinophil cationic protein, IL-4, and IL-13, among others). Notably, in allergic subjects, these cells exist in higher numbers and in a more activated state compared with nonatopic control subjects. Evidence for the greater activation state… CONTINUE READING