Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

  title={Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells},
  author={Tatiana I. Novobrantseva and Anna Borodovsky and Jamie Wong and Boris Klebanov and Mohammad R. Zafari and Kristina Yucius and William Querbes and P. Q. Ge and Vera M. Ruda and Stuart Milstein and Lauren Speciner and Rick Duncan and Scott A. Barros and G. Reddy Basha and Pieter R Cullis and Akin Akinc and Jessica S. Donahoe and K Narayanannair Jayaprakash and Muthusamy Jayaraman and Roman L. Bogorad and Kevin T. Love and Katie Whitehead and Chris Levins and Muthiah Manoharan and Filip K Swirski and Ralph Weissleder and Robert S Langer and Daniel G Anderson and Antonin R de Fougerolles and Matthias Nahrendorf and Victor Koteliansky},
  booktitle={Molecular therapy. Nucleic acids},
Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) to immune cells could thus enable novel treatment strategies with broad applicability. In this report, we develop systemic delivery methods of siRNA encapsulated in lipid nanoparticles (LNP) for durable and potent in vivo RNA interference (RNAi)-mediated silencing in… CONTINUE READING
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