Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.

@article{Winston2002SystemicRI,
  title={Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.},
  author={William M Winston and Christina Molodowitch and Craig P. Hunter},
  journal={Science},
  year={2002},
  volume={295 5564},
  pages={2456-9}
}
Double-stranded RNA-mediated gene interference (RNAi) in Caenorhabditis elegans systemically inhibits gene expression throughout the organism. To investigate how gene-specific silencing information is transmitted between cells, we constructed a strain that permits visualization of systemic RNAi. We used this strain to identify systemic RNA interference-deficient (sid) loci required to spread gene-silencing information between tissues but not to initiate or maintain an RNAi response. One of… CONTINUE READING
Highly Influential
This paper has highly influenced 34 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
308 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 308 extracted citations

Similar Papers

Loading similar papers…