Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients

@inproceedings{Bergenfelz2015SystemicMA,
  title={Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients},
  author={Caroline Bergenfelz and A Larsson and Kristoffer von Stedingk and Sofia K. Gruvberger-Saal and Kristina E. Aaltonen and Sara Jansson and Helena C.B. Jernstr{\"o}m and Helena Janols and Marlene Wullt and Anders C A Bredberg and Lisa Ryd{\'e}n and Karin Leandersson and Robert M Lafrenie},
  booktitle={PloS one},
  year={2015}
}
Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface… CONTINUE READING
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