Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China

Abstract

UNLABELLED Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. METHODS Inpatient medical records of SLE-related AP were retrospectively reviewed. RESULTS 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score (21.70 ± 10.32 versus 16.17 ± 7.51, P = 0.03), more organ systems involvement (5.70 ± 1.56 versus 3.96 ± 1.15, P = 0.001), and higher mortality (37.04% versus 0, P = 0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, P = 0.014). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis. CONCLUSION SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP.

DOI: 10.1155/2012/568564

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@inproceedings{Yang2012SystemicLupusErythematosusRelatedAP, title={Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China}, author={Yanlong Yang and Yujin Ye and Liuqin Liang and Tianfu Wu and Zhongping Zhan and Xiuyan Yang and Hanshi Xu}, booktitle={Clinical & developmental immunology}, year={2012} }