Systemic Lipopolysaccharide Induces Cochlear Inflammation and Exacerbates the Synergistic Ototoxicity of Kanamycin and Furosemide

@article{Hirose2014SystemicLI,
  title={Systemic Lipopolysaccharide Induces Cochlear Inflammation and Exacerbates the Synergistic Ototoxicity of Kanamycin and Furosemide},
  author={Keiko Hirose and S Li and Kevin K. Ohlemiller and Richard M Ransohoff},
  journal={Journal of the Association for Research in Otolaryngology},
  year={2014},
  volume={15},
  pages={555-570}
}
Aminoglycoside antibiotics are highly effective agents against gram-negative bacterial infections, but they cause adverse effects on hearing and balance dysfunction as a result of toxicity to hair cells of the cochlea and vestibular organs. While ototoxicity has been comprehensively studied, the contributions of the immune system, which controls the host response to infection, have not been studied in antibiotic ototoxicity. Recently, it has been shown that an inflammatory response is induced… CONTINUE READING
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