Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.

  title={Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.},
  author={Liya Qin and Xuefei Wu and Michelle L. Block and Yuxin Liu and George R. Breese and Jau-Shyong Hong and Darin J. Knapp and Fulton T Crews},
  volume={55 5},
Inflammation is implicated in the progressive nature of neurodegenerative diseases, such as Parkinson's disease, but the mechanisms are poorly understood. A single systemic lipopolysaccharide (LPS, 5 mg/kg, i.p.) or tumor necrosis factor alpha (TNFalpha, 0.25 mg/kg, i.p.) injection was administered in adult wild-type mice and in mice lacking TNFalpha receptors (TNF R1/R2(-/-)) to discern the mechanisms of inflammation transfer from the periphery to the brain and the neurodegenerative… CONTINUE READING
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