Systemic Injections of Cannabidiol Enhance Acetylcholine Levels from Basal Forebrain in Rats

  title={Systemic Injections of Cannabidiol Enhance Acetylcholine Levels from Basal Forebrain in Rats},
  author={Eric Murillo-Rodr{\'i}guez and Gloria Arankowsky-Sandoval and Nuno Barbosa Rocha and Rodrigo Peniche-Amante and Andr{\'e} Barciela Veras and S{\'e}rgio Machado and Henning Budde},
  journal={Neurochemical Research},
Cannabis sativa is a plant that contains more than 500 components, of which the most studied are Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Several studies have indicated that CBD displays neurobiological effects, including wake promotion. Moreover, experimental evidence has shown that injections of CBD enhance wake-related compounds, such as monoamines (dopamine, serotonin, epinephrine, and norepinephrine). However, no clear evidence is available regarding the effects of CBD on… 

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