Systemic Injections of Cannabidiol Enhance Acetylcholine Levels from Basal Forebrain in Rats

@article{MurilloRodrguez2018SystemicIO,
  title={Systemic Injections of Cannabidiol Enhance Acetylcholine Levels from Basal Forebrain in Rats},
  author={Eric Murillo-Rodr{\'i}guez and Gloria Arankowsky-Sandoval and Nuno Barbosa Rocha and Rodrigo Peniche-Amante and Andr{\'e} Barciela Veras and S{\'e}rgio Machado and Henning Budde},
  journal={Neurochemical Research},
  year={2018},
  volume={43},
  pages={1511-1518}
}
Cannabis sativa is a plant that contains more than 500 components, of which the most studied are Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Several studies have indicated that CBD displays neurobiological effects, including wake promotion. Moreover, experimental evidence has shown that injections of CBD enhance wake-related compounds, such as monoamines (dopamine, serotonin, epinephrine, and norepinephrine). However, no clear evidence is available regarding the effects of CBD on… 

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References

SHOWING 1-10 OF 71 REFERENCES

Prohedonic Effect of Cannabidiol in a Rat Model of Depression

The results suggest that CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia, now shown for the first time in a genetic animal model of depression.

Cannabidiol Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System

A novel NAcVTA circuit is demonstrated responsible for the behavioral and neuronal effects of CBD within the mesolimbic system via functional interactions with serotonergic 5-HT1A receptor signaling.

Neurophysiological evidence for the presence of cannabinoid CB1 receptors in the laterodorsal tegmental nucleus

CB1Rs are functionally active in the LDT, and their activation changes the firing frequency and synaptic activity of neurons in this nucleus, which concludes that endogenous eCB transmission could play a role in processes involving the L DT.

Effects of cannabinoids on levels of acetylcholine and choline and on turnover rate of acetylcholine in various regions of the mouse brain.

The most consistent effects of cannabinoids, both psychotomimetic and nonpsychotomimetics, were to increase ACh and decrease ACh turnover in the hippocampus.

The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent.

Findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.

The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism

It is concluded that in particular the non-psychotropic CBD might be useful for the treatment of mood disorders in patients with inflammatory diseases, since this cannabinoid seems to be safe and its effects on activation-induced tryptophan degradation by CBD were more potent as compared to THC.
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