Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

@article{Kikuchi2002SystemicIO,
  title={Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy},
  author={A. Kikuchi and A. Takeda and H. Onodera and T. Kimpara and K. Hisanaga and N. Sato and A. Nunomura and R. Castellani and G. Perry and Mark A. Smith and Y. Itoyama},
  journal={Neurobiology of Disease},
  year={2002},
  volume={9},
  pages={244-248}
}
8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Compared to age-matched controls, the mean levels of serum 8-OHdG/8-OHG were significantly higher in PD (P < 0.0001). Although no gender differences were observed in the controls… Expand
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