Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles.

@article{Ramishetti2015SystemicGS,
  title={Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles.},
  author={Srinivas Ramishetti and Ranit Kedmi and Meir Goldsmith and Fransisca Leonard and Andrew G. Sprague and Biana Godin and Michael Gozin and Pieter R Cullis and Derek Michael Dykxhoorn and Dan Peer},
  journal={ACS nano},
  year={2015},
  volume={9 7},
  pages={6706-16}
}
Modulating T cell function by down-regulating specific genes using RNA interference (RNAi) holds tremendous potential in advancing targeted therapies in many immune-related disorders including cancer, inflammation, autoimmunity, and viral infections. Hematopoietic cells, in general, and primary T lymphocytes, in particular, are notoriously hard to transfect with small interfering RNAs (siRNAs). Herein, we describe a novel strategy to specifically deliver siRNAs to murine CD4(+) T cells using… CONTINUE READING
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