Systemic Fate of the Adipocyte-Derived Factor Adiponectin

  title={Systemic Fate of the Adipocyte-Derived Factor Adiponectin},
  author={Nils H. Halberg and Todd D. Schraw and Zhao V Wang and Ja-Young Kim and James Yi and Mark Patrick Hamilton and Kate Luby-Phelps and Phillip E Scherer},
OBJECTIVE The adipocyte-derived secretory protein adiponectin has been widely studied and shown to have potent insulin-sensitizing, antiapoptotic, and anti-inflammatory properties. While its biosynthesis is well understood, its fate, once in circulation, is less well established. RESEARCH DESIGN AND METHODS Here, we examine the half-life of adiponectin in circulation by tracking fluorescently labeled recombinant adiponectin in the circulation, following it to its final destination in the… CONTINUE READING

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Plasma adiponecN

T Schraw, ZV Wang, N Halberg, M Hawkins, PE. Scherer

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