Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study.

@article{Bhatia2015SystemicET,
  title={Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study.},
  author={Smita Bhatia and Wendy Landier and Lindsey Hageman and Yanjun Chen and Heeyoung Kim and C Z Sun and Nancy M Kornegay and William E. Evans and Anne L. Angiolillo and Bruce C Bostrom and Jacqueline N Casillas and Glen Lew and Kelly W. Maloney and Leo Mascarenhas and Arthur Kim Ritchey and Amanda M. Termuhlen and William L Carroll and Florence Lennie Wong and Mary V. Relling},
  journal={JAMA oncology},
  year={2015},
  volume={1 3},
  pages={287-95}
}
IMPORTANCE Variability in prescribed doses of 6-mercaptopurine (6MP) and lack of adherence to a 6MP treatment regimen could result in intra-individual variability in systemic exposure to 6MP (measured as erythrocyte thioguanine nucleotide [TGN] levels) in children with acute lymphoblastic leukemia (ALL). The effect on relapse risk of this variability is unknown. OBJECTIVE To determine the effect of high intra-individual variability of 6MP systemic exposure on relapse risk in children with ALL… CONTINUE READING
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