Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

@article{McAllister2008SystemicEI,
  title={Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin},
  author={Sandra S McAllister and Ann M. Gifford and Ashley L. Greiner and Stephen P. Kelleher and Matthew P. Saelzler and Tan A. Ince and Ferenc Reinhardt and Lyndsay N. Harris and Bonnie L. Hylander and Elizabeth A. Repasky and Robert A Weinberg},
  journal={Cell},
  year={2008},
  volume={133},
  pages={994-1005}
}
The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find that human breast carcinomas instigate the growth of otherwise-indolent tumor cells, micrometastases, and human tumor surgical specimens located at distant anatomical sites. This systemic instigation is accompanied by incorporation of bone-marrow cells (BMCs) into the stroma of the distant, once-indolent tumors. We find that BMCs of hosts… CONTINUE READING
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