Systemic Delivery of Oncolytic Viruses: Hopes and Hurdles

  title={Systemic Delivery of Oncolytic Viruses: Hopes and Hurdles},
  author={M Sharon Ferguson and Nicholas R. Lemoine and Yaohe Wang},
  booktitle={Advances in virology},
Despite recent advances in both surgery and chemoradiotherapy, mortality rates for advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one option is systemic oncolytic viral therapy. Intravenous administration affords the opportunity to treat both the primary tumour and any metastatic deposits simultaneously. Data from clinical trials have shown that oncolytic viruses can be systemically delivered safely with limited toxicity but the results are equivocal in… CONTINUE READING