Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons.

@article{Yoshii2016SystemicAO,
  title={Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons.},
  author={Saori R. Yoshii and A. C. S. Kuma and Takumi Akashi and Taichi Hara and Atsushi Yamamoto and Yoshitaka Kurikawa and Eisuke Itakura and Satoshi Tsukamoto and Hiroshi Shitara and Yoshinobu Eishi and Noboru Mizushima},
  journal={Developmental cell},
  year={2016},
  volume={39 1},
  pages={116-130}
}
Autophagy is a cytoplasmic degradation system that is important for starvation adaptation and cellular quality control. Previously, we reported that Atg5-null mice are neonatal lethal; however, the exact cause of their death remains unknown. Here, we show that restoration of ATG5 in the brain is sufficient to rescue Atg5-null mice from neonatal lethality. This suggests that neuronal dysfunction, including suckling failure, is the primary cause of the death of Atg5-null neonates, which would… CONTINUE READING
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