Systematic variation in gene expression patterns in human cancer cell lines

@article{Ross2000SystematicVI,
  title={Systematic variation in gene expression patterns in human cancer cell lines},
  author={Douglas Teller Ross and Uwe Scherf and Michael B. Eisen and Charles M. Perou and Christian A. Rees and Paul T. Spellman and Vishwanath R. Iyer and Stefanie S. Jeffrey and Matt van de Rijn and Mark Waltham and Alexander Pergamenschikov and Jeffrey C. Lee and Deval A. Lashkari and Dari Shalon and Timothy G. Myers and John N. Weinstein and David Botstein and Patrick O. Brown},
  journal={Nature Genetics},
  year={2000},
  volume={24},
  pages={227-235}
}
We used cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-cancer drugs. Classification of the cell lines based solely on the observed patterns of gene expression revealed a correspondence to the ostensible origins of the tumours from which the cell lines were derived. The consistent relationship between the gene expression patterns and the tissue of origin allowed us to… 
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