Systematic synthesis and inhibitory activity of haloacetamidyl oligosaccharide derivatives toward cytoplasmic peptide:N-glycanase

@article{Miyazaki2008SystematicSA,
  title={Systematic synthesis and inhibitory activity of haloacetamidyl oligosaccharide derivatives toward cytoplasmic peptide:N-glycanase},
  author={A. Miyazaki and Ichiro Matsuo and Shinya Hagihara and A. Kakegawa and T. Suzuki and Y. Ito},
  journal={Glycoconjugate Journal},
  year={2008},
  volume={26},
  pages={133-140}
}
  • A. Miyazaki, Ichiro Matsuo, +3 authors Y. Ito
  • Published 2008
  • Medicine, Chemistry
  • Glycoconjugate Journal
  • A series of glycosyl haloacetamides were synthesized as potential inhibitors of cytoplasmic peptide:N-glycanase (PNGase), an enzyme that removes N-glycans from misfolded glycoproteins. Chloro-, bromo-, and iodoacetamidyl chitobiose and chitotetraose derivatives exhibited a significant inhibitory activity. No inhibitory activity was observed with of fluoroacetamididyl derivatives. Moreover, N-acetylglucosamine derivatives, β-chloropropionamidyl chitobiose, and chloroacetamidyl… CONTINUE READING
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