Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

@inproceedings{Noble2010SystematicSO,
  title={Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity},
  author={Suzanne M. Noble and Sarah D French and Lisa A. Kohn and Victoria Chen and Alexander Johnson},
  booktitle={Nature Genetics},
  year={2010}
}
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissection of virulence mechanisms. Published analyses of such mutants show a near-perfect correlation between C. albicans pathogenicity and the ability to undergo a yeast-to-hypha morphological switch in vitro. However, most studies have used mutants constructed with a marker that is itself a virulence… CONTINUE READING
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Disruption of the Candida albicans ATC 1 gene encoding a celllinked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress

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