Systematic review with meta‐analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea

  title={Systematic review with meta‐analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea},
  author={Samuel Aldred Slattery and O S Niaz and Qasim Aziz and Alexander Charles Ford and Adam D. Farmer},
  journal={Alimentary Pharmacology \& Therapeutics},
Irritable bowel syndrome is a widespread disorder with a marked socioeconomic burden. Previous studies support the proposal that a subset of patients with features compatible with diarrhoea‐predominant IBS (IBS‐D) have bile acid malabsorption (BAM). 

Review article: an analysis of safety profiles of treatments for diarrhoea‐predominant irritable bowel syndrome

  • B. Lacy
  • Medicine
    Alimentary pharmacology & therapeutics
  • 2018
A broad range of therapies is available to manage symptoms of this common disorder, and a wide range of procedures are available to diagnose and treat IBS.

An approach to the care of patients with irritable bowel syndrome

IBS is a disorder of gut–brain interaction characterized by abdominal pain associated with a change in frequency or form of bowel habit, and accounts for more than 40% of irritable bowel syndrome cases.

Irritable bowel syndrome: enigmatic for doctors, problematic for patients

Although in Europe IBS more often presents in women, men also suffer and this potential diagnosis should not be overlooked.

Long‐term effect of medical treatment of diarrhoea in 377 patients with SeHCAT scan diagnosed bile acid malabsorption from 2003 to 2016; a retrospective study

Diagnosis is possible by measuring the retention fraction of orally ingested 75Selenium homotaurocholic acid (SeHCAT), which indicates excessive amounts of bile acids entering the colon due to bile Acid malabsorption cause chronic bile acid diarrhoea.

Review article: bile acid diarrhoea – pathogenesis, diagnosis and management

Bile acid diarrhoea results from imbalances in the homoeostasis of bile acids in the enterohepatic circulation. It can be a consequence of ileal disease/dysfunction, associated with other GI

Longitudinal follow‐up of a novel classification system for irritable bowel syndrome: natural history and prognostic value

This work derived and validated a latent class model subgrouping people with IBS into seven clusters based on gastrointestinal and extraintestinal symptoms and psychological profile.

Prognosis of patients with Rome IV‐defined versus physician‐diagnosed irritable bowel syndrome: Longitudinal follow‐up study

A longitudinal follow‐up study examining the differences between patients diagnosed with irritable bowel syndrome by a physician who meet the Rome IV criteria for IBS and those who do not is conducted.

Does your patient have bile acid malabsorption

The synthesis, enterohepatic circulation, and function of bile acids are briefly reviewed followed by a discussion of biles acid malabsorption.

Up-to-Date Diagnosis and Management of IBS and Chronic Constipation in Primary Care.

The goal of this monograph will focus on emerging treatment updates, reviewing current treatment guidelines, and advances in the management of irritable bowel syndrome (IBS).

Review Article: Current and future treatment approaches for IBS with diarrhoea (IBS‐D) and IBS mixed pattern (IBS‐M)

Treatment of irritable bowel syndrome‐diarrhoea and IBS‐M is aimed at multiple mechanisms such as altering gut microbiota, visceral hypersensitivity, intestinal permeability, gut‐brain interaction and psychological strategies.



Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea‐predominant irritable bowel syndrome

Recurrent, watery diarrhoea affects one‐third of patients diagnosed with irritable bowel syndrome and Idiopathic bile acid malabsorption (‘I‐BAM’) may be the cause.

Review article: the economic impact of the irritable bowel syndrome

A large number of people worldwide have IBS, and it has substantial impact on patients' quality of life (QoL) and is associated with considerable healthcare resource use.

Systematic review: the management of chronic diarrhoea due to bile acid malabsorption

Bile acid malabsorption (BAM) is a common, yet under‐recognised, cause of chronic diarrhoea, with limited guidance available on the appropriate management of patients with BAM.

Screening for bile acid diarrhoea in suspected irritable bowel syndrome

It is demonstrated that 18% of patients who meet criteria for IBS may have underlying bile acid diarrhoea (BAD), using 23-seleno-25-homo-tauro-cholic acid (SeHCAT) scanning.

Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea

Yield of 23‐seleno‐25‐homo‐tauro‐cholic acid (SeHCAT) scanning in chronic diarrhea patients is examined, and predictors of a positive test are attempted to identify.

Applicability of the reported prevalence of bile salt malabsorption in irritable bowel

  • A. Ford
  • Medicine
    Alimentary pharmacology & therapeutics
  • 2010
This study purports to be a systematic review of the prevalence of bile salt malabsorption in IBS, yet from the supplementary materials available online, it would appear that only seven of the studies stated specifically that they included individuals with IBS and only one of these used accepted symptom-based criteria to make the diagnosis (Rome II).

Systematic review of diagnostic criteria for IBS demonstrates poor validity and utilization of Rome III

A systematic review is conducted to examine the validation and utilization of IBS criteria and finds that clinical criteria used in this study are valid and effective.

Post‐infectious irritable bowel syndrome: The past, the present and the future

  • U. GhoshalPrabhat Ranjan
  • Medicine
    Journal of gastroenterology and hepatology
  • 2011
Post‐infectious IBS (PI‐IBS), defined as acute onset IBS after gastrointestinal infection in an individual without prior IBS with two or more of the followings: fever, vomiting, diarrhea, a positive stool culture.

Bile acid malabsorption: An under-investigated differential diagnosis in patients presenting with diarrhea predominant irritable bowel syndrome type symptoms

BAM is common and should be considered earlier when investigating unselected patients with D-IBS type symptoms as demonstrated by a positive SeHCAT test (retention <10% at seven days).

High Prevalence of Idiopathic Bile Acid Diarrhea Among Patients With Diarrhea-Predominant Irritable Bowel Syndrome Based on Rome III Criteria.