Systematic review with meta‐analysis: the efficacy and safety of tenofovir to prevent mother‐to‐child transmission of hepatitis B virus

@article{Hyun2017SystematicRW,
  title={Systematic review with meta‐analysis: the efficacy and safety of tenofovir to prevent mother‐to‐child transmission of hepatitis B virus},
  author={Myung Han Hyun and Y-S Lee and J H Kim and Ji Hye Je and Yang Jae Yoo and Jong Eun Yeon and Kwan Soo Byun},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2017},
  volume={45},
  pages={1493 - 1505}
}
  • M. Hyun, Y-S Lee, K. Byun
  • Published 1 June 2017
  • Medicine, Biology
  • Alimentary Pharmacology & Therapeutics
Preventing mother to child transmission of chronic hepatitis B infection in the setting of a high maternal viral load is challenging. The idea has emerged from antepartum tenofovir treatment with combination immunoprophylaxis. 
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55 Citations
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55 Citations

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Citation Type

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TLDR
The benefits of different antiviral regimens in pregnant women with hepatitis B virus (HBV) infection are explored in an attempt to provide scientific reference for clinically relevant interventions.
Letter: role of tenofovir to prevent mother‐to‐child transmission of hepatitis B virus
TLDR
In their meta-analysis, tenofovir significantly reduced the risk of infant hepatitis B surface antigen seropositivity by 77%, which meant that 23% infant continued to have HBV infection.
Mother‐to‐child transmission of hepatitis B: What more needs to be done to eliminate it around the world?
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This review highlights the efficacy and barriers of the currently validated measures for the prevention of HBV MTCT and proposes alternatives adapted to resource‐limited settings to eventually achieve HBV elimination worldwide.
Accelerating progress towards the elimination of mother‐to‐child transmission of HIV: a narrative review
Findings from biomedical, behavioural and implementation studies provide a rich foundation to guide programmatic efforts for the prevention of mother‐to‐child HIV transmission (PMTCT).
Prevention of maternal-to-child transmission of hepatitis B: a narrative review
TLDR
This review summarises the experience in Hong Kong and the current recommendations to prevent HBV vertical transmission and describes a wide range of preventive strategies to decrease maternal-to-child transmission.
Evidence for Use of Tenofovir in Pregnancy to Prevent Perinatal Transmission of Hepatitis B Infection
TLDR
This chapter is a review of current studies that have provided strong evidence for the efficacy and safety of 3 antiviral drugs in pregnancy—lamivudine, telbivUDine and tenofovir.
Efficacy and Safety of Tenofovir in the Prevention of Perinatal Transmission of Hepatitis B, a Meta-Analysis.
Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis
TLDR
In pregnant women who have high HBV DNA titers, TDF can reduce the perinatal transmission from mother to child without significant adverse events.
Letter: role of tenofovir to prevent mother‐to‐child transmission of hepatitis B virus—authors’ reply
TLDR
A phase III, placebocontrolled, double-blind, randomized clinical trial to assess the efficacy and safety of a short course of tenofovir disoproxil fumarate in women with hepatitis B virus e-antigen.
Identifying gaps across the cascade of care for the prevention of HBV mother‐to‐child transmission in Burkina Faso: Findings from the real world
TLDR
This pilot study aimed to describe the cascade of care for hepatitis B PMTCT in a real life situation, and to identify sociodemographic factors associated with adequate management of pregnant women and infants.
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