• Corpus ID: 44827725

Systematic review of the non-specific effects of BCG , DTP and measles containing vaccines

@inproceedings{SoaresWeiser2014SystematicRO,
  title={Systematic review of the non-specific effects of BCG , DTP and measles containing vaccines},
  author={Soares-Weiser},
  year={2014}
}
Evidence of Increase in Mortality After the Introduction of Diphtheria–Tetanus–Pertussis Vaccine to Children Aged 6–35 Months in Guinea-Bissau: A Time for Reflection?
TLDR
Although having better nutritional status and being protected against three infections, 6–35 months old DTP-vaccinated children tended to have higher mortality than D TP-un vaccinated children.
Cost-effectiveness of providing measles vaccination to all children in Guinea-Bissau
TLDR
Taking the low cost of MV and the beneficial non-specific effects of MV into consideration, a 10-dose MV vial should be reclassified as a ‘1+ dose vial’.
Immunological considerations regarding parental concerns on pediatric immunizations.
TLDR
Current immunization schedules have been developed and tested to avoid vaccine interference, improve benefits and reduce side effects compared to single administrations, and show that vaccines can overcome those suboptimal features of infant immune system that render them more at risk of infections and of their severe manifestations.
Sex-differential heterologous (non-specific) effects of vaccines: an emerging public health issue that needs to be understood and exploited
TLDR
This review discusses the evidence, mechanisms and public health implications of the non-specific effects of vaccines (NSEs), including sex-differential effects, and describes how advances in systems biology might be applied to study such effects.
The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment
TLDR
DTP was associated with increased mortality; OPV may modify the effect of DTP; the introduction of diphtheria-tetanus-pertussis and oral polio vaccine in Guinea-Bissau in the early 1980s was examined.
Introduction of standard measles vaccination in an urban African community in 1979 and overall child survival: a reanalysis of data from a cohort study
TLDR
MV may have beneficial non-specific effects on child survival not related to the prevention of measles infection as the unvaccinated children did not die of Measles infection.
Randomized Trials Comparing Inactivated Vaccine After Medium- or High-titer Measles Vaccine With Standard Titer Measles Vaccine After Inactivated Vaccine: A Meta-analysis.
TLDR
Mortality in girls was higher when they had received inactivated vaccines (after MTMV or HTMV) rather than live standard titer MV (after an inactivated vaccine) after 9 months of age.
Revaccination with Live Attenuated Vaccines Confer Additional Beneficial Nonspecific Effects on Overall Survival: A Review
TLDR
Findings challenge current understanding of vaccines and may explain the beneficial effects of campaigns with live vaccines.
The WHO Review of the Possible Non-Specific Effects of Diphtheria-Tetanus-Pertussis Vaccine.
TLDR
Bias does not seem to explain why DTP is associated with higher mortality, and the observed inconsistencies in results were due to methodologic differences between studies.
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References

SHOWING 1-10 OF 51 REFERENCES
Non‐specific sex‐differential effect of DTP vaccination may partially explain the excess girl child mortality in Ballabgarh, India
TLDR
To test the hypothesis that a gender differential exists in the effect on child mortality of BCG, DTP, measles vaccine as administered under programme conditions in Ballabgarh HDSS area, a large number of children in the area have received the measles vaccine.
Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial
TLDR
Even though the children with the best nutritional status were vaccinated early, early DTP vaccination was associated with increased mortality for girls, and small mid-upper arm circumference was the strongest predictor of mortality.
Non-specific and sex-differential effects of vaccinations on child survival in rural western India.
TLDR
BCG out-of-sequence may be associated with lower mortality than DTP as the most recent vaccination, given the public health implications, and this possibility should be tested in randomized trials.
Non‐specific effects of diphtheria‐tetanus‐pertussis and measles vaccinations? An analysis of surveillance data from Navrongo, Ghana
TLDR
Examining the impact of vaccinations on child mortality in Navrongo, Ghana found measles vaccine is associated with lower mortality and diphtheria‐tetanus‐pertussis with relatively higher mortality.
The impact of immunization on the association between poverty and child survival: Evidence from Kassena-Nankana District of northern Ghana
TLDR
Findings show that the adverse effects of poverty disappear and that the effects of educational attainment are reduced in survival models that control for immunization status, lending empirical support to policies that promote immunization as a strategic component of poverty-reduction programmes.
Sex Differential Effects of Routine Immunizations and Childhood Survival in Rural Malawi
TLDR
The female–male mortality ratio varied with age, and BCG, DTP1 and MV had differential effects for girls and boys like in previous studies from West Africa.
Benefits of routine immunizations on childhood survival in Tari, Southern Highlands Province, Papua New Guinea.
TLDR
Routine immunizations are effective in reducing overall mortality in young children in an area of high mortality, in contrast to findings reported from Guinea-Bissau.
Evaluation of non‐specific effects of infant immunizations on early infant mortality in a southern Indian population
Objective  The aim of this study was to assess the relationship between receipt of routine childhood immunizations and infant mortality before 6 months of age.
Effect of infant immunisation on childhood mortality in rural Bangladesh: analysis of health and demographic surveillance data
TLDR
Diphtheria-tetanus-pertussis (DTP) and oral polio vaccination were independently associated with decreased risk of death before age 9 months, as were amount of maternal education, maternal age, and birth order of the child.
Non-specific effects of vaccination on child survival: prospective cohort study in Burkina Faso
TLDR
Vaccination with diphtheria, tetanus, and pertussis as well as BCG is associated with better survival of children up to 2 years of age.
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