Systematic review of the effect of education on survival in Alzheimer's disease
@article{Paradise2009SystematicRO, title={Systematic review of the effect of education on survival in Alzheimer's disease}, author={Matt Paradise and Claudia Cooper and Gill Livingston}, journal={International Psychogeriatrics}, year={2009}, volume={21}, pages={25 - 32} }
ABSTRACT Background: According to the cognitive reserve model, higher levels of education compensate for the neuropathology of Alzheimer's disease (AD), delaying its clinical manifestations. This model suggests that for any level of cognitive impairment, people with more education have worse neuropathology than those with less education and will therefore have shorter survival post-diagnosis. This is the first systematic review of the relationship between more education and decreased survival…
87 Citations
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References
SHOWING 1-10 OF 49 REFERENCES
Does cognitive status modify the relationship between education and mortality? Evidence from the Canadian Study of Health and Aging
- Psychology, MedicineInternational Psychogeriatrics
- 2004
These findings do not support previous work that showed a higher risk of mortality among highly educated dementia subjects, and no relationship exists between education and mortality.
Cognitive Decline and Survival in Alzheimer’s Disease according to Education Level
- MedicineDementia and Geriatric Cognitive Disorders
- 2007
In this cohort of 670 Alzheimer’s disease patients, highly educated patients had a faster cognitive decline than less educated patients but similar mortality rates, supporting the cognitive reserve hypothesis.
Effects of educational attainment on the clinical expression of Alzheimer's disease: Results from a research registry
- PsychologyAmerican journal of Alzheimer's disease and other dementias
- 2001
It is concluded that, for subjects in the authors' sample, education had modest effects on aspects of the clinical expression of AD, but these effects were not fully consistent with predictions derived from the “reserve” hypothesis.
Increased risk of mortality in Alzheimer's disease patients with higher education? A replication study
- MedicineNeurology
- 1997
It is concluded that higher education is not associated with increased risk of mortality in AD patients and that difference in populations used is considered to be most important, which might explain the conflicting results.
Influence of Premorbid IQ and Education on Progression of Alzheimer’s Disease
- Psychology, MedicineDementia and Geriatric Cognitive Disorders
- 2006
It is concluded that a baseline AMNART score is a better predictor of cognitive change in AD than education, but neither variable is associated with survival after diagnosis.
Increased risk of mortality in alzheimer's disease patients with more advanced educational and occupational attainment
- MedicineAnnals of neurology
- 1995
It is suggested that education systematically influences global ratings of disease severity or that education provides a reserve against the clinical manifestation of AD pathology, resulting in shorter duration of diagnosed disease before death.
Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease
- PsychologyAnnals of neurology
- 1992
It is concluded that education or its covariates or both may provide a reserve that compensates for the neuropathological changes of AD and delays the onset of its clinical manifestations.
The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen Project.
- MedicineArchives of neurology
- 2001
A low level of education is related to an increased incidence of clinical AD or dementia, but not to the mortality of subjects with AD or schizophrenia, which can be accounted for by the "cognitive reserve" hypothesis.
Rate of cognitive decline and mortality in Alzheimer’s disease
- Medicine, PsychologyNeurology
- 2003
Mortality in AD is strongly associated with rate of cognitive decline, and risk of death was increased more than threefold in the subgroup with mild decline, more than fivefold in those with moderately rapid decline,and more than eightfold inThose with the most rapid decline.
Education and Alzheimer disease without dementia
- Medicine, PsychologyNeurology
- 2007
The theory that individuals with greater cognitive reserve, as reflected in years of education, are better able to cope with AD brain pathology without observable deficits in cognition is supported.