Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia.

  title={Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia.},
  author={Nadine Dougall and S. M. Bruggink and Klaus P. Ebmeier},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  volume={12 6},
  • N. DougallS. BrugginkKlaus P. Ebmeier
  • Published 1 November 2004
  • Medicine, Psychology
  • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
OBJECTIVE The authors sought to determine the diagnostic accuracy of 99mTc-HMPAO-SPECT in discriminating between Alzheimer disease (AD) and other dementias. METHODS Articles published between 1985 and 2002 were retrieved systematically from MEDLINE and EMBASE, cross-referencing with personal collections and 13 narrative reviews. Of 301 studies identified, 48 survived exclusion criteria and contained extractable data. Two authors independently assessed and graded the methodology of all… 

Systematic review of the diagnostic utility of SPECT imaging in dementia

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Contribution of single photon emission computed tomography to the differential diagnosis of dementia in a memory clinic.

Compared with clinical diagnosis alone, SPECT imaging improved the specificity of the etiological diagnosis in degenerative dementia, although its sensitivity was not as good as that of clinical diagnosis.

Sensitivity and Specificity of Diagnostic Accuracy in Alzheimer’s Disease

Cerebrospinal fluid-tau and various positron emission tomography approaches showed a similar range of sensitivity and specificity as diagnostic protocols, and issues that remain in the study of AD diagnosis include the need to determine the comparative effectiveness of diagnostic approaches.

The Diagnostic Utility of 99mTc-HMPAO SPECT Imaging: A Retrospective Case Series from a Tertiary Referral Early-Onset Cognitive Disorders Clinic

The results suggest that SPECT imaging may be a useful adjunct to clinical evaluation and a more sensitive biomarker than standard structural imaging.

Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer’s disease

Technetium-99-labelled hexamethyl propylene amine oxime SPECT CBF patterns provide valuable information in the diagnosis of FTD and AD, and can be better used as an adjunct to clinical diagnosis if pathology is to be correctly predicted in life.

Value of neuropsychological testing, imaging, and CSF biomarkers for the differential diagnosis and prognosis of clinically ambiguous dementia.

In conclusion, CSF biomarkers efficiently predict evolution toward an AD phenotype in CAD by contributing to the differential diagnosis between non-AD dementias and MRI and SPECT contributed mostly to the diagnosis of VaD and FTD.

Vascular dementia Diagnostic criteria and supplementary exams

The present paper aims to define guidelines on the basic principles for treating patients with suspected VaD (and vascular cognitive impairment – no dementia) using an evidence-based, systematized approach.

Confirmation rate of blinded 99mTc-SPECT compared to neurochemical dementia biomarkers in CSF in patients with Alzheimer disease

In 76 patients blinded 99mTc-SPECT was compared to CSF, confirming that CSF biomarkers show higher sensitivity and SPECT has higher specificity and can also be used for other dementias without established CSf biomarkers.

18F-FDG PET and Perfusion SPECT in the Diagnosis of Alzheimer and Lewy Body Dementias

18F-FDG PET was significantly superior to blood flow SPECT for the differential diagnosis of degenerative dementia and should be performed instead of perfusion SPECT if functional imaging is indicated.

Diagnosis and treatment of dementia: 2. Diagnosis Review

Practical guidance is provided on the diagnosis of dementia based on recommendations from the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia, held in March 2006, and evidence-based guidelines are developed.



Sensitivity, Specificity, and Positive Predictive Value of Technetium 99-HMPAO SPECT in Discriminating Alzheimer's Disease from other Dementias

A pattern of TP on SPECT scans is seen in most patients with AD, but could be found in other dementias as well and cannot be regarded as specific to AD.

Regional HmPAO SPECT and CT Measurements in the Diagnosis of Alzheimer's Disease

The measurements of left temporal cortical atrophy and regional cerebral blood flow were most indicative of AD; however they lacked the sensitivity and specificity to recommend their use as a diagnostic test for AD.

Brain SPECT in dementia. A clinical-scintigraphic correlation.

SPECT and CT showed similar accuracy in the diagnosis of dementia and the quite high specificity of SPECT in Alzheimer's disease may be useful for confirming that diagnosis, particularly for patients with presenile onset of the disease.

99mTc-HMPAO-SPECT in the diagnosis of senile dementia of Alzheimer's type — a study under clinical routine conditions

99mTc-HMPAO SPECT is a valuable additional tool in the differential diagnosis of depression and dementia in the elderly and is most prominent in the left parieto-occipital ROI.

99Tcm-HMPAO SPECT in suspected dementia

SPECT with 99Tcm-HMPAO seems to be useful in the diagnosis of suspected dementia, and in patients with depression or anxiety SPECT was abnormal in 16/21 cases, suggesting that SPECT may give early clues to the presence of an underlying organic disease in such elderly patients.

The Diagnostic Value of Magnetic Resonance Imaging and Technetium 99m‐HMPAO Single‐Photon-Emission Computed Tomography for the Diagnosis of Alzheimer Disease in a Community‐Dwelling Elderly Population

Assessment of the diagnostic value for Alzheimer disease (AD) of single-photon-emission computed tomography (SPECT) and magnetic resonance imaging (MRI) separately and in combination found that using MRI only would be the most cost-effective approach.

Discriminative use of SPECT in frontal lobe-type dementia versus (senile) dementia of the Alzheimer's type.

Technetium-99m-HMPAO SPECT may help in discriminating FLD from (S)DAT, and bifrontal hypoperfusion was found to be the most powerful predictor of clinical classification.

Differentiation between Alzheimer's disease and multi‐infarct dementia: Spect vs MR imaging

The findings suggest that Tc‐99m HMPAO SPECT is a useful and practical tool in the assessment of patients with dementia and enables the differential diagnosis of dementia and by using semiquantitative data it helps to establish the severity of disease.

SPECT perfusion imaging in the diagnosis of Alzheimer’s disease

In the evaluation of dementia, SPECT imaging can provide clinically useful information indicating the presence of AD in addition to the information that is obtained from clinical evaluation.

Toward a definite diagnosis of Alzheimer's disease.