Systematic review of physical and chemical compatibility of commonly used medications administered by continuous infusion in intensive care units

@article{Kanji2010SystematicRO,
  title={Systematic review of physical and chemical compatibility of commonly used medications administered by continuous infusion in intensive care units},
  author={Salmaan Kanji and Jason Lam and Christel Johanson and Avinder Singh and Rob D Goddard and Jennifer Fairbairn and Tammy Lloyd and Daniel Monsour and Juzer A. Kakal},
  journal={Critical Care Medicine},
  year={2010},
  volume={38},
  pages={1890-1898}
}
OBJECTIVE To quantify the physical and chemical stability data published for commonly used continuously infused medications in the intensive care unit and to evaluate the quality of the studies providing these data. [...] Key MethodDATA SOURCES AND STUDY SELECTION We conducted a systematic electronic literature search of MEDLINE, EMBASE, and International Pharmaceutical Abstracts as well as the references of electronic drug compatibility textbooks for all English and French language research publications…Expand
Compatibility of drugs administered as Y-site infusion in intensive care units: A systematic review
TLDR
This review provides new reliable evidence about the physicochemical stability of drugs commonly used in the critical care setting and contributes to the safe administration of intravenous drugs in critical patients with a view to avoiding adverse events in this frail population. Expand
Physical Compatibility of Intravenous Drugs Commonly Used in Intensive Care Units: An Observational Study and Physical Compatibility Laboratory Tests on Anti-Infective Drugs
TLDR
The objective was to identify injectable drugs administered by Y-site infusion or mixed in the same container, to compare with physical compatibility data available in the literature and to test the physical compatibility for missing data. Expand
Investigations of Physical Compatibilities of Commonly Used Intravenous Medications with and without Parenteral Nutrition in Pediatric Cardiovascular Intensive Care Unit Patients
TLDR
This study demonstrates the utility of simulated Y-site study design to multi-drug combinations and increases the scientific body of knowledge related to medications used in a pediatric CVICU. Expand
Physicochemical compatibility of commonly used analgesics and sedatives in the intensive care medicine
TLDR
4-Hydroxybutyric acid carries a major risk for incompatibilities when mixed with other drugs and therefore has to be administered separately and should only be used with great caution, and a dose adjustment should be considered. Expand
Physicochemical compatibility of high concentration drugs usually Y-site administered in intensive care units
TLDR
This study provides information about the physicochemical compatibility of ordinary mixtures, at high concentrations, commonly used in intensive care units, that might help to improve drug safety management in the critically ill patient. Expand
Medication Safety in Intravenous Therapy: A Compatibility Study and Analysis of Reaction Products of Dihydralazine and Metamizole
TLDR
The findings demonstrate that the intravenous co-administration of dihydralazine and metamizole should be strictly avoided due to the incompatibility of these two drugs. Expand
Compatibility of medications during multi-infusion therapy: A controlled in vitro study on a multilumen infusion device.
TLDR
The results confirm that the Edelvaiss Multiline-8 device prevents physical drug incompatibilities under specified conditions and is therefore advantageous, especially when simultaneously infusing two or four incompatible drugs. Expand
Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units
TLDR
Alprostadil was compatible with 13 drugs commonly used in neonatal intensive care units and incompatibility could not be ruled out for 3 drugs (cisatracurium, dexmedetomidine and noradrenalin), and insulin was considered incompatible with alProstadil. Expand
Compatibility of Commonly Used IV Drugs
These factors contribute to the escalating complexity of IV drug administration and have resulted in an ever-increasing number of possible incompatibilities. The potential for serious andExpand
Medication Safety in Intravenous Therapy: A Compatibility Study of Clonidine with Drugs Frequently Used in Intensive Care
TLDR
Clonidine can be coadministered with dihydralazine, levosimendan, metamizole, milrinone, urapidil, and verapamil, however, the concomitant administration of clonidine with amiodarone or furosemide is not recommended. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 122 REFERENCES
Physical Compatibility of Pantoprazole with Selected Medications during Simulated Y-Site Administration
TLDR
Admixtures prepared in the clinical setting are subject to greater error than in the laboratory, and it is therefore recommended that practitioners avoid Y-site administration of pantoprazole with dobutamine, esmolol, midazolam, octreotide, or norepinephrine (at concentrations near or greater than 1.5 μg/mL). Expand
Combined administration of opioids with selected drugs to manage pain and other cancer symptoms: initial safety screening for compatibility.
TLDR
The results of a study evaluating the physical compatibility of injectable opioids with selected drugs for pain and symptom management found Fentanyl citrate, hydromorphone hydrochloride, methadone hydrochlorides, and morphine sulfate solutions were physically compatible with 14 of 15 supportive care drugs tested. Expand
Physical and chemical compatibility of drotrecogin alfa (activated) with 34 drugs during simulated Y-site administration.
  • H. Mann, Sarah L Demmon, +6 authors G. Gopalrathnam
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2004
TLDR
Ceftriaxone, cisatracurium, fluconazole, nitroglycerin, potassium chloride, and vasopressin were physically and chemically compatible with drotrecogin alfa in a simulated Y-site infusion; 28 other drugs were incompatible with droTrecog in alfa. Expand
Physical compatibility and in vivo evaluation of drug mixtures for subcutaneous infusion to cancer patients in palliative care
TLDR
Very good symptom control was obtained with all of the drug mixtures investigated, and especially with the mixture of morphine + midazolam + haloperidol + hyoscine, which is the one most frequently administered to cancer patients for palliative care in the final stages of life in the authors' Unit. Expand
Propofol Compatibility with other Intravenous Drug Products—Two New Methods of Evaluating IV Emulsion Compatibility
TLDR
The new methods were useful in detecting incompatibilities in emulsions and should not mix the immediately incompatible products with propofol by administering them in the same intravenous line. Expand
Stability of midazolam and fentanyl in infusion solutions.
TLDR
Fentanyl was found to be very stable when stored at temperatures ranging from 5 degrees C to 38 degrees C for at least 1 week and midazolam was not as stable as fentanyl under the same storage conditions and underwent time-dependent decomposition. Expand
Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
TLDR
The compatibility of 102 drugs with parenteral nutrient (PN) solutions during simulated Y-site administration was studied and 20 drugs exhibited various incompatibilities with one or more of the PN solutions. Expand
Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
TLDR
Most of the test drugs were physically compatible with the nine representative 3-in-1 parenteral nutrition admixtures, however, the 23 drugs that resulted in incompatibilities should not be administered simultaneously with the incompatible parenTERal Nutrition admixtures via a Y injection site. Expand
Stability of labetalol hydrochloride with selected critical care drugs during simulated Y-site injection.
TLDR
The compatibility and stability of labetalol hydrochloride in combination with various critical care drugs was evaluated and were stable and compatible for up to four hours at 20-25 degrees C during simulated Y-site injection. Expand
Compatibility and stability of labetalol hydrochloride in commonly used intravenous solutions.
TLDR
Compatibility and stability of labetalol hydrochloride when mixed with commonly used large-volume parenterals (LVPs) were tested and no measurable change in pH or osmolarity occurred. Expand
...
1
2
3
4
5
...