Systematic review of clinical trials of small- and large-gel-particle hyaluronic acid injectable fillers for aesthetic soft tissue augmentation.

@article{Cohen2013SystematicRO,
  title={Systematic review of clinical trials of small- and large-gel-particle hyaluronic acid injectable fillers for aesthetic soft tissue augmentation.},
  author={Joel E. Cohen and Steven H Dayan and Fredric S Brandt and Diane B Nelson and Robert A Axford-Gatley and Michael J. Theisen and Rhoda S. Narins},
  journal={Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]},
  year={2013},
  volume={39 2},
  pages={205-31}
}
BACKGROUND Hyaluronic acid (HA) is the most frequently injected filler for soft tissue augmentation in the United States. OBJECTIVE To systematically review published evidence for aesthetic use of small- and large-gel-particle HA. METHODS AND MATERIALS Clinical data on anatomic area, level of evidence, patient population, trial design, endpoints, efficacy, and safety were extracted from PubMed. RESULTS Fifty-three primary clinical reports were analyzed. The highest-quality efficacy… CONTINUE READING