Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever

@article{Southey2009SystematicRA,
  title={Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever},
  author={Elizabeth R Southey and K. Soares-Weiser and J. Kleijnen},
  journal={Current Medical Research and Opinion},
  year={2009},
  volume={25},
  pages={2207 - 2222}
}
ABSTRACT Objective: The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age. Methods: MEDLINE (1950 to November 2008), EMBASE (1980 to November 2008), The Cochrane Library (2007, Issue 3), ACP Journal Club (1991 to November 2007) and Pascal (1987 to November 2007) were searched for randomised controlled trails (RCTs) (comparing ibuprofen and/or paracetamol with… Expand
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The ibuprofen plus paracetamol FDC is conclusively an effective analgesic against placebo in acute postoperative, moderate to severe pain in adults and it is also superiorly well tolerated, including at the higher dose of 292.5 mg; however, safety outcomes were inconclusive. Expand
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