Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever

@article{Southey2009SystematicRA,
  title={Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever},
  author={Elizabeth R Southey and Karla Soares-Weiser and Jos Kleijnen},
  journal={Current Medical Research and Opinion},
  year={2009},
  volume={25},
  pages={2207 - 2222}
}
ABSTRACT Objective: The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age. Methods: MEDLINE (1950 to November 2008), EMBASE (1980 to November 2008), The Cochrane Library (2007, Issue 3), ACP Journal Club (1991 to November 2007) and Pascal (1987 to November 2007) were searched for randomised controlled trails (RCTs) (comparing ibuprofen and/or paracetamol with… 
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The Cochrane Review on combining and alternating acetaminophen and ibuprofen for treating fever in children found some evidence that both alternating and combined antipyretic therapy may be more effective at reducing temperatures than monotherapy alone.

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A single 10mg/kg dose of intravenous ibuprofen provided a significant reduction of temperature for febrile pediatric patients compared to those that received 10 mg/kg acetaminophen at 2 h and 4 h post-treatment.

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IBU pediatric suspension provided greater temperature reduction versus acetaminophen in febrile children, with a comparable safety profile, and individual and pooled secondary efficacy outcomes supported significant advantages of IBU over APAP.

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