Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease.

  title={Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease.},
  author={Renata Micha and Fumiaki Imamura and Moritz C. Wyler von Ballmoos and Daniel H. Solomon and Miguel A. Hern{\'a}n and Paul M. Ridker and Dariush Mozaffarian},
  journal={The American journal of cardiology},
  volume={108 9},
Inflammation predicts risk for cardiovascular disease (CVD) events, but the relation of drugs that directly target inflammation with CVD risk is not established. Methotrexate is a disease-modifying antirheumatic drug broadly used for the treatment of chronic inflammatory disorders. A systematic review and meta-analysis of evidence of relations of methotrexate with CVD occurrence were performed. Cohorts, case-control studies, and randomized trials were included if they reported associations… CONTINUE READING
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Systematic review and meta - analysis of methotrexate use and risk of cardiovascular disease

DH Solomon, MA Hernán, D Mozaffarian