Systematic review and meta‐analysis: is 1‐week proton pump inhibitor‐based triple therapy sufficient to heal peptic ulcer?

@article{Gisbert2005SystematicRA,
  title={Systematic review and meta‐analysis: is 1‐week proton pump inhibitor‐based triple therapy sufficient to heal peptic ulcer?},
  author={Javier P. Gisbert and Jos{\'e} David Mart{\'i}nez Pajares},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2005},
  volume={21}
}
Aims : To systematically review the efficacy on ulcer healing of 1‐week combination of a proton pump inhibitor plus two antibiotics and to perform a meta‐analysis of randomized clinical trials to evaluate whether 7 days of proton pump inhibitor‐based triple therapy is sufficient to heal peptic ulcer. 
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Whether it is a requirement to continue with anti-secretory therapy following anti-Helicobacter therapy in H. pylori positive gastric ulcers is an important question, and clinicians will likely err on the side of caution and continue acid suppressive therapy to ensure healing of gastric Ulcers.
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TLDR
Clinicians will continue to rely on PPIs to control acid secretion in GERD and other acid-related diseases and two novel drugs (namely ilaprazole and tenatoprazole) are being studied in humans.
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TLDR
The aim of the study was to determine the annual recurrence rate of H. pylori, in Brazilian patients with peptic ulcer disease, in a 5-year follow-up.
Gastric ulcer treatment: cure of Helicobacter pylori infection without subsequent acid-suppressive therapy: is it effective?
TLDR
Whether it is a requirement to continue with anti-secretory therapy following anti-Helicobacter therapy in H. pylori positive gastric ulcers is an important question, and clinicians will likely err on the side of caution and continue acid suppressive therapy to ensure healing of gastric Ulcers.
Treatment of Helicobacter pylori
TLDR
A simulation model suggested by the Cochrane review group showed that H. pylori eradication is cost‐effective for duodenal and gastric ulcer long‐term and the duration of eradication therapy continues to be controversial.
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