Systematic review: tolerable amount of gluten for people with coeliac disease

@article{Akobeng2008SystematicRT,
  title={Systematic review: tolerable amount of gluten for people with coeliac disease},
  author={A K Akobeng and Adrian G. Thomas},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2008},
  volume={27}
}
Background  The threshold amount of gluten in ‘gluten‐free’ products that can be tolerated by people with coeliac disease is unclear. 
Symptomatic suspected gluten exposure is common among patients with coeliac disease on a gluten‐free diet
TLDR
A gluten‐free diet is the only recommended treatment for coeliac disease and it is important to select patients suitable for a gluten-free diet based on their medical history.
Systematic review: the evidence base for long‐term management of coeliac disease
TLDR
This data indicates that a gluten‐free diet is an effective treatment for coeliac disease but the need for and goals of long‐term management of patients are poorly defined.
The burden of celiac disease and the value of having it diagnosed
TLDR
A small number of patients diagnosed with celiac disease have shown an intolerance to gluten that is similar to that of a food allergy, and these patients are referred to a gluten-free clinic for further studies.
Celiac disease and Infections
TLDR
A small number of patients with a history of celiac disease and/or high-risk of gluten-related illnesses are diagnosed with atypical central giant cell granuloma, which is a leading cause of death in people with Celiac disease.
Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten‐free diet
TLDR
It is shown that following a gluten‐free diet with a probiotic supplement increases the likelihood of healing of small intestinal mucosa in coeliac patients and reduces the risk of disease in adults.
Demographics, clinical features and treatment of pediatric celiac disease
Celiac disease (CD) is a chronic small intestinal immune-mediated enteropathy triggered by ingestion of gluten-containing food in genetically predisposed subjects. The enteropathy is presented with
Systematic review: adherence to a gluten‐free diet in adult patients with coeliac disease
TLDR
A large number of patients with coeliac disease who present with atypical symptoms or who are asymptomatic and detected by case screening are not adherent to a gluten‐free diet, and the factors associated with non‐adherence are understood.
Helping Adults With Celiac Disease to Eat Well
TLDR
This review focuses on helping adults with celiac disease to manage their eating and to achieve a high quality of life.
Gluten in Celiac Disease—More or Less?
TLDR
The literature was reviewed to evaluate the upper limit for gluten content in food, which would be safe for patients with celiac disease and most health authorities define gluten-free products as containing less than 20 parts per million gluten.
...
...

References

SHOWING 1-10 OF 49 REFERENCES
Review article: safe amounts of gluten for patients with wheat allergy or coeliac disease
TLDR
Estimation of the maximum tolerated amount of gluten for susceptible individuals would support effective management of their disease.
The safe threshold for gluten contamination in gluten‐free products. Can trace amounts be accepted in the treatment of coeliac disease?
TLDR
This work has shown that gluten contamination in gluten‐free products cannot totally be avoided and the safe threshold for gluten remains obscure.
Oats in the treatment of childhood coeliac disease: a 2‐year controlled trial and a long‐term clinical follow‐up study
TLDR
The exclusion of oats from the diet in coeliac disease is controversial, and oats-free diets are considered to be a viable treatment option for the disease.
Wheat‐starch‐based gluten‐free products in the treatment of newly detected coeliac disease: prospective and randomized study
TLDR
The safety of wheat‐starch‐based gluten‐free products in the treatment of coeliac disease is debatable and further studies are needed to determine whether these products are safe and effective in the presence of gluten.
Effects of small amounts of gluten in the diet of coeliac patients.
TLDR
All present evidences give strong support for advising all patients to adhere to a strict GFD for life, in view of the recently reported protective effect of GFD against malignancies.
Gluten-free diet--what is toxic?
Are all gliadins toxic in coeliac disease? An in vitro study of alpha, beta, gamma, and w gliadins.
TLDR
The results suggest that all these gliadin fractions are toxic to coeliac mucosa in vitro.
Low gluten diet in the treatment of adult coeliac disease: effect on jejunal morphology and serum anti-gluten antibodies.
TLDR
It is concluded that adult coeliac patients can tolerate a LGD without gross morphological change and without initiating significant AG antibody responses.
Evaluation of a gliadin-containing gluten-free product in coeliac patients.
TLDR
A cross-over study was carried out in which ten treated coeliac patients ingested six slices daily of home-baked gliadin-containing gluten-free bread for 6 weeks, while jejunal biopsy morphometry and 51Cr-EDTA excretion were similar after the test and control periods.
Persistent mucosal abnormalities in coeliac disease are not related to the ingestion of trace amounts of gluten.
TLDR
The persistent mucosal abnormalities seen in patients with coeliac disease on a GFD are not due to the ingestion of trace amounts of gluten.
...
...