Systematic review: the use of serology to exclude or diagnose coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests)

@article{Lewis2006SystematicRT,
  title={Systematic review: the use of serology to exclude or diagnose coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests)},
  author={Nina Ruth Lewis and B. B. Scott},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2006},
  volume={24}
}
With the appreciation of the high prevalence of coeliac disease there is increasing use of serology in screening asymptomatic people and testing those with suggestive features. 
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TLDR
Discrepancies between histology and serology for the diagnosis of coeliac disease (CD) are inevitable, given the fact that, even measurement of transglutaminase autoantibodies (TGAA) is now considered to be the most efficient single test for CD diagnosis.
Discrepancies between histology and serology for the diagnosis of coeliac disease (1).
TLDR
There are major reasons to reduce the reliance on serology testing in diagnosing and excluding coeliac disease, and the use of histology and serology should be reduced.
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TLDR
The use of biopsy and antibodies in coeliac disease diagnosis is reviewed at theSymposium to discuss the role of these instruments and their applications in clinical practice.
The presence of anti‐endomysial antibodies and the level of anti‐tissue transglutaminases can be used to diagnose adult coeliac disease without duodenal biopsy
The new ESPGHAN guidelines for diagnosis of paediatric coeliac disease suggest to avoid biopsy in genetically pre‐disposed and symptomatic individuals with positive anti‐endomysial antibodies (EMA)
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In this review; the definition of celiac disease, etiopathogenesis, clinical and histopathologic characteristics are viewed especially for childhood.
Noncoeliac enteropathy: the differential diagnosis of villous atrophy in contemporary clinical practice
TLDR
Duodenal villous atrophy is a key diagnostic finding in coeliac disease (CD), however, the differential diagnosis for this finding is broad.
Celiac Disease: Clinical Features and Diagnosis.
Comparison of non‐invasive tests with invasive tests in the diagnosis of celiac disease
TLDR
In selected children patients, the need for invasive tests is ceased and adult patients according to the ESPGHAN (European Pediatric Gastroenterology Hepatology and Nutrition Society) criteria are evaluated.
Investigation and management of coeliac disease
TLDR
The accuracy of serological testing has improved dramatically with targeted assessment of children with conditions known to be associated with CD leading to the detection of asymptomatic cases, which still requires upper gastrointestinal endoscopy and small bowel biopsy.
Pre-endoscopic serological test with duodenal biopsy in high risk patients had high sensitivity and low specificity for coeliac disease
TLDR
Pre-endoscopy serological testing for coeliac disease: evaluation of a clinical decision tool and its application in clinical practice.
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